In the field of pharmaceutical intermediate production,It is the key to ensure product quality and production efficiency that efficient and accurate separation and purification technology . Shandong Liancui Fluid Technology Co., Ltd., with its advanced centrifugal extraction machine technology, provides efficient and energy-saving solutions for the production of pharmaceutical intermediates, significantly improving product quality and production efficiency.

Case Background

A large pharmaceutical intermediate production enterprise in Jiangxi faced problems such as low efficiency, high energy consumption, and difficulty in ensuring product purity of traditional extraction equipment during the production process. Especially when dealing with certain high-viscosity and easily emulsified pharmaceutical intermediate solutions, traditional equipment is prone to emulsification, resulting in poor separation effect and serious impact on product quality. In order to solve these problems, the company decided to introduce Shandong Liancui Fluid Technology Co., Ltd.'s LC series centrifugal extractor for process upgrade.

Equipment Section-Centerifugal extractor
LC series centrifugal extractor has many significant advantages. It adopts an independent mixing chamber design, the drum is only responsible for separation, and the stirring paddle can be customized according to the viscosity of the material, which effectively avoids the emulsification phenomenon caused by the drum participating in the mixing of the traditional annular gap extractor. The speed of the equipment can be adjusted within the range of 5000-8000rpm, generating a supergravity field (the centrifugal force is more than 1000 times the gravity), so that the two-phase liquid can be mixed and separated in milliseconds, greatly improving the extraction efficiency. In addition, the main body of the equipment adopts a composite structure of 316L stainless steel + fluorine material, which can withstand strong corrosive media such as hydrofluoric acid and sulfuric acid, ensuring the stable operation and long life of the equipment.

Application process introduction

Raw material introduction
The leachate containing the target pharmaceutical intermediate and the organic extractant are introduced into the mixing chamber of the centrifugal extractor through the feed port respectively. In the mixing chamber, the stirring paddle rotates at high speed, so that the leachate and the extractant are fully contacted and mixed to form a complex.

Efficient separation
Under the centrifugal force generated by the high-speed rotating drum, the denser water phase (containing impurities) is thrown to the drum wall, while the less dense organic phase (loaded with the target pharmaceutical intermediate) is concentrated in the central area to achieve efficient separation. The separated two-phase liquid is discharged from the equipment through different outlets.

Multi-stage of centrifugal extractor series connection
In order to further improve the purity of the product, the company adopted a multi-stage series connection process. Multiple LC series centrifugal extractors are connected in series, so that the leaching liquid and the extractant are extracted and separated in turn in the multi-stage equipment. By adjusting the speed and ratio (O/A) of each stage of the equipment, the separation efficiency of each stage is optimized.
Application effect

Improved extraction efficiency
Compared with traditional extraction equipment, the extraction efficiency of the LC series centrifugal extractor has been significantly improved. In the production of a certain pharmaceutical intermediate, the single-stage extraction rate has increased from the original 60% to more than 85%, and the extraction rate can reach more than 95% after multi-stage series connection.

Improved product purity
Through the multi-stage series connection process, the purity of the target pharmaceutical intermediate has been greatly improved. In a certain case, the product purity has increased from the original 80% to more than 99%, meeting the needs of the high-end pharmaceutical market.

Reduced energy consumption
The LC series centrifugal extractor adopts a non-annular gap mixing design, and the drum itself does not participate in the mixing, and the energy consumption is reduced by more than 20% compared with traditional equipment. At the same time, the intelligent control system of the equipment can automatically adjust the operating parameters according to the actual working conditions, further reducing energy consumption.

Reduced operation and maintenance costs
The corrosion resistance and stable operation of the equipment reduce the number of equipment maintenance and repair costs. In addition, the application of intelligent control systems reduces the risk of manual intervention and reduces labor costs. According to company statistics, after the introduction of the LC series centrifugal extractor, the operation and maintenance costs have been reduced by more than 30%.

Conclusion
The LC series centrifugal extractor of Shandong Liancui Fluid Technology Co., Ltd. has shown excellent application advantages in the production of pharmaceutical intermediates. Its efficient and precise separation technology, excellent corrosion resistance and intelligent control system have solved the problems of traditional extraction equipment for enterprises, improved product quality and production efficiency, and reduced production costs and operation and maintenance costs. With the continuous development of pharmaceutical intermediate production technology, the LC series centrifugal extractor will play a more important role in this field and help enterprises achieve green and efficient production.